Personalized Medicine

Project Member

Kenneth Cromack

The goal of this quarter

Create a program which calculates risk from multiple disease causing mutations.

Project Description

With the number of disease causing associations being discovered, we can measure the risk of an individual having the disease. How can we achieve this, and when will it be useful?

Relevant Files
Project Write-Up (PDF)
Project Presentation Slides (PPT)

April 19, 2008

Personalized Medicine Project started!

April 21, 2008

What I did this week: Selected a topic, and created the wiki page.
What I plan to do next week: Research disease causing mutations, and determine the best way to approach the project.
How what you did compared to what you planned to do: Perfectly.
What grade you think you deserve for your work on the project for the week: A+

May 1, 2008

What I did this week: Due to midterms, I did not complete as much as I wanted to. Did research into 23andMe and Navigenics regarding their process of genotype analysis and calculating lifetime risk for specific diseases.
What I plan to do next week: Continue my research, and try to isolate specific disease causing mutations.
How what you did compared to what you planned to do: Fairly well, though not as much as I wanted.
What grade you think you deserve for your work on the project for the week: B

May 9, 2008

What I did this week: Using the HapMap data, catalogued a number of specific markers related to the occurrence of specific common diseases, namely Alzheimer's, multiple sclerosis, and rheumatoid arthritis.
What I plan to do next week: Begin programming a working prototype program to calculate estimated risks based on some sample of the observed markers.
How what you did compared to what you planned to do: Very well, I found a lot of valuable data.
What grade you think you deserve for your work on the project for the week: A

May 16, 2008

What I did this week: Re-evaluated the equations to serve as the foundation for my program.
What I plan to do next week: Program a working program to calculate estimated risks based on some sample of the observed markers.
How what you did compared to what you planned to do: Needed to backtrack a little, but it was necessary to be certain I'm heading in the right direction.
What grade you think you deserve for your work on the project for the week: B+

May 23, 2008

What I did this week: After spending some time working with the equations, decided that an executable program would not be the most optimal means of representing acquired data. Decided to present a simpler representation of the data with more tangible and easily perceivable results.
What I plan to do next week: Keep working with equations to determine best way to represent data.
How what you did compared to what you planned to do: Again, needed to backtrack, though I least have a better feeling of what is and isn't an optimal way to present the data I collect.
What grade you think you deserve for your work on the project for the week: B

May 30, 2008

What I did this week: Chose to represent my data in Excel, decided to show instances of a single disease-causing mutation, along with two independently caused mutations.
What I plan to do next week: Tabulate a sample of the data I observe, and prepare it for presentation on June 6.
How what you did compared to what you planned to do: Definitely accomplished what I wanted to this week, found a way to represent my data, and the specific context in which to process my desired calculations.
What grade you think you deserve for your work on the project for the week: A

June 6, 2008

What I did this week: Clarified terminology and differences between environmental risk and prevalence. Finished up necessary calculations for one disease-causing mutation, tabulated results, presented my project to the remainder of the class.
What I plan to do next week: Finish calculating for cases with two disease-causing mutations,and generate the corresponding tables.
How what you did compared to what you planned to do: Presentation went very well, and I was able to accomplish the majority of my calculations. Overall, I accomplished what I wanted to this week.
What grade you think you deserve for your work on the project for the week: A

June 11, 2008
What I did this week:Finished up necessary calculations for two disease-causing mutation, tabulated results, submitted my final project write-up, along with my updated presentation slides containing new data tables.
What I plan to do next week: Enjoy the first week of summer!
How what you did compared to what you planned to do: Completed everything of relevance to the project. Overall, excellent job!
What grade you think you deserve for your work on the project for the week: A

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